Rapid Publication Encapsulation of Rat Islets of Langerhans Prolongs Xenog raft Survival in Diabetic Mice
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چکیده
Rat islets encapsulated in alginate-polylysine membranes were implanted intraperitoneally into nonimmunosuppressed streptozocin-induced diabetic mice. Diabetes was reversed within 3 days, and the animals remained normoglycemic for up to 144 days, with a mean xenograft survival of 80 days. This was significantly greater than nonencapsulated islets, which functioned for <14 days. The graft survival rate at 50 days was >80%. Xenografts of rat islets encapsulated in alginate-polyornithine membranes also had a prolonged survival rate. This study demonstrates that encapsulation of pancreatic islets in semipermeable membranes can prolong xenograft survival in the absence of immunosuppreSSion. DIABETES 1986; 35:943-46.
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